Endocrine Abstracts

A 38-year-old woman presented with symptoms suggesting Cushing’s syndrome. She has a history of surgery of mature ovarian teratoma (hysterectomy, ovarectomy) associated to radio and chemotherapy 15 years ago. The malignant teratoma relaps with hepatic and grelic metastases, and was unresectable. Main complaints were weight gain with centripetal fat distribution, muscle weakness, melanodermia and purpule striae on the skin of the abdomen, thighs, breasts and arms....

Introduction: Insulinoma is rare tumor with an incidence of 1 in 250,000 patient-years. It presents with repeated episodes of hypoglycemia due to endogenous hyperinsulinemia, which occurs mostly in the fasting state. Insulinomas are usually sporadic, solitary, benign and encapsulated small lesions and majority of them measure <2 cm in diameter. They pose a challenge for pre-operative localization.Materials and methods: A retrospective study of patien...

Introduction: Thiamine responsive megaloblastic anemia (TRMA) syndrome, also known Rogers syndrome is a rare autosomal recessive inherited disorder characterized by a triad features of megaloblastic anemia, sensorineural deafness and diabetes mellitus. TRMA manifestation is caused by mutations in the gene SLC19A2 encoding a high-affinity thiamine transporter, which disturbs the active thiamine uptake into cells.Case Presentation...

Introduction: GH deficiency (GHD) represents less than 20% of short stature in children, the clinical, biological and radiological characteristics differ from one population to another.Methods: Our retrospective study describe 59 children (37 boys and 22 girls) with confirmed GHD. The average age of discovery was 95 months. About 20.3% of these children were born from a consanguineous marriage. Family history of anterior pituitary insufficiency was prese...